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Can You Mix Niacinamide with Vitamin C?

Skincare myths can often lead to confusion, especially when it comes to mixing ingredients like Niacinamide and Vitamin C. Contrary to popular belief, using these two powerhouse ingredients together can be beneficial for your skin. This article aims to clear up the misconception and provide evidence-based insights into how combining Niacinamide with Vitamin C can enhance your skincare routine.


The Myth: Niacinamide and Vitamin C Shouldn't Be Mixed

Historically, the misconception that niacinamide and vitamin C should not be mixed originated from early research, which suggested potential negative interactions and stability issues when these ingredients are combined. This outdated viewpoint implied that such a mix could lead to reduced effectiveness of both compounds, possibly affecting the skin's pH balance and leading to irritation. Modern studies, however, have proven these concerns unfounded, demonstrating that Niacinamide and Vitamin C can coexist harmoniously in skincare routines, offering amplified benefits without compromising their individual strengths.

To best understand why combining Niacinamide with Vitamin C in skincare products is not only safe but beneficial, we must first understand their individual benefits.

Benefits of Niacinamide in Skincare

Niacinamide, also known as Vitamin B3, stands out in skincare for its multifaceted benefits, supporting skin health in several ways:

  • Strengthens Skin Barrier: Enhances the skin's natural defense mechanism, reducing vulnerability to external aggressors and preventing moisture loss.
  • Soothes Inflammation: Offers anti-inflammatory benefits, making it ideal for calming redness and irritation.
  • Balances Oil Production: Regulates sebum, aiding in controlling excess oiliness.
  • Improves Skin Tone: Contributes to a more even complexion by addressing discoloration.
  • Minimizes Pores: Helps reduce the appearance of enlarged pores for smoother skin.
  • Reduces Fine Lines: Assists in diminishing the visibility of fine lines through skin hydration and resilience improvement.

As such, Niacinamide can help with various skin concerns, including:

  • Acne and breakouts
  • Rosacea and skin redness
  • Hyperpigmentation and uneven skin tone
  • Signs of aging, including fine lines and wrinkles
  • Enlarged pores

By targeting these concerns, Niacinamide emerges as a versatile ingredient suitable for a wide range of skincare routines, offering a well-rounded approach to maintaining healthy, resilient skin.

Benefits of Vitamin C in Skincare

Vitamin C, a potent antioxidant, is revered in skincare for its ability to:

  • Protect Against Environmental Damage: Shields skin from harmful UV rays and pollution.
  • Boost Collagen Production: Vital for maintaining skin's elasticity and firmness.
  • Brighten Skin Tone: Helps fade pigmentation and even out skin tone.
  • Reduce Signs of Aging: Diminishes the appearance of fine lines and wrinkles.

Vitamin C can address the following skin concerns:

  • Dullness and uneven texture
  • Dark spots and hyperpigmentation
  • Loss of firmness and elasticity

By addressing these issues, Vitamin C is a key ingredient for anyone looking to revitalize and protect their skin, promoting a radiant, youthful complexion. 
PRO TIP: Choose a Vitamin C serum with a concentration of at least 10% Vitamin C. Anything less is likely to be ineffective.

FAQ's: Combining Niacinamide and Vitamin C

Can You Mix Niacinamide with Vitamin C?

Modern research affirms the compatibility of Niacinamide and Vitamin C in skincare routines. Whether combined within a single product or applied in layers from separate products, this dynamic duo enhances skin health without causing irritation, thanks to their distinct yet synergistic benefits. If your skin is especially sensitive or sensitized after a treatment such as microneedling or laser resurfacing, consider a serum that combines these ingredients with anti-inflammatory and healing ingredients such as Lavender.

What are the Benefits of Using Niacinamide and Vitamin C Together?

Combining Niacinamide with Vitamin C amplifies their individual advantages, offering a holistic approach to skin care:


Niacinamide: This skin-restorative agent significantly improves the look of enlarged pores, fine lines, and lackluster skin.

Vitamin C: Known for its potent antioxidant properties, it shields the skin from environmental stressors and addresses signs of aging.


Together, they tackle uneven skin tones, wrinkles, firmness issues, and dullness, suitable for all skin types, paving the way for a more radiant, smoother, and youthful complexion.

How Should You Layer Niacinamide and Vitamin C for Best Results?

Both Niacinamide and Vitamin C are versatile, found in a variety of skincare formulations from cleansers to moisturizers. To get the best results from each ingredients, make sure that the products you are mixing are synergistic and effective.  As such, prioritize leave-on forms such as toners, serums, or moisturizers, allowing these nutrients ample time to work on the skin.


The choice of product texture should cater to your specific skin needs and type. Universally, serums and boosters with lightweight formulations are recommended for their compatibility with diverse skin types, ensuring easy absorption without heaviness. For moisturizers, consider your skin's moisture requirements: oilier profiles benefit from lighter formulations, while dry skin types achieve better hydration and protection with richer, more emollient creams.

Which Should You Apply First: Vitamin C or Niacinamide?

Ideally, you can use a product that contains both. This helps ensure that you are using synergistic ingredients and also not overusing a particular ingredient, which can cause irritation. Layering should follow the product consistency rule, from thinnest to thickest. If using a Niacinamide booster and a Vitamin C moisturizer, apply the booster first. There's no need to wait between applications, as these ingredients work well immediately one after the other, without affecting each other’s absorption or benefits.

Is It Better to Use Niacinamide and Vitamin C Together in the Morning or at Night?

Niacinamide and Vitamin C can be used both in the morning and at night. Morning application, especially, boosts your sunscreen’s protection against environmental damage. While Vitamin C is particularly beneficial for daytime use for its antioxidant properties, Niacinamide is also effective and can be included in morning routines.

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